--- gcc/config/mips/mips.c
+++ gcc/config/mips/mips.c
@@ -3131,6 +3131,12 @@
       emit_insn (gen_update_got_version ());
     }
 
+  if (TARGET_MIPS16 && TARGET_USE_GOT)
+    {
+      clobber_reg (&CALL_INSN_FUNCTION_USAGE (insn), MIPS16_PIC_TEMP);
+      clobber_reg (&CALL_INSN_FUNCTION_USAGE (insn), MIPS_PROLOGUE_TEMP (word_mode));
+    }
+
   if (TARGET_MIPS16
       && TARGET_EXPLICIT_RELOCS
       && TARGET_CALL_CLOBBERED_GP)