--- gcc/cfgcleanup.c
+++ gcc/cfgcleanup.c
@@ -53,6 +53,7 @@
 #include "dce.h"
 #include "dbgcnt.h"
 #include "rtl-iter.h"
+#include "regs.h"
 
 #define FORWARDER_BLOCK_P(BB) ((BB)->flags & BB_FORWARDER_BLOCK)
 
@@ -1217,6 +1218,14 @@
 		}
 	    }
 	}
+
+      HARD_REG_SET i1_used, i2_used;
+
+      get_call_reg_set_usage (i1, &i1_used, call_used_reg_set);
+      get_call_reg_set_usage (i2, &i2_used, call_used_reg_set);
+
+      if (!hard_reg_set_equal_p (i1_used, i2_used))
+        return dir_none;
     }
 
   /* If both i1 and i2 are frame related, verify all the CFA notes